Publications

2025

Breunig, M., Hohwieler, M., Haderspeck, J., von Zweydorf, F., Hauff, N., Pasquini, L.-P., Wiegreffe, C., Zimmer, E., Mulaw, M. A., Julier, C., Simon, E., Gloeckner, C. J., Liebau, S. and Kleger, A. ( 2025), PPDPF is not a key regulator of human pancreas development. PLoS Genet. 2025, e1011657.  doi:101371/journal.pgen.1011657

Vinci, E., Beretta, S., Colombo, V., Zippo, A., Catanese, A., Wiegreffe, C., Britsch, S., Boeckers, T., Verpelli, C. and Sala, C. ( 2025), Regulation of Dendrite and Dendritic Spine Formation by TCF20. J Neurochem, 169: e16297.  doi.org/10.1111/jnc.16297

Barbian, B, Shiozawa, T., Gellisch, M., Brunk, I., Langer-Fischer, K., Wagner, N., Benker, S., Bellstedt, M., Otto, N., Darici, D. (2025), Anatomy learning profiles in relation to studend motivation and academic success: A multi-center cross-sectional study. Anatomical Science Education, 2025. doi:10.1002/ase.70065

2024

Kazuki Okuyama, Motoi Yamashita, Artemis Koumoundourou, Christoph Wiegreffe, Michiko Ohno-Oishi, Samuel JH Murphy, Xin Zhao, Hideyuki Yoshida, Takashi Ebihara, Naoko Satoh-Takayama, Satoshi Kojo, Hiroshi Ohno, Tomohiro Morio, Yibo Wu, Jennifer Puck, Hai-Hui Xue, Stefan Britsch & Ichiro Taniuchi. A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development. Nature Immunology 2024, doi.org/10.1038/s41590-024-01997-5

Neumann AM, Britsch S. Molecular Genetics of Acquired Temporal Lobe Epilepsy. Biomolecules. 2024 Jun 7;14(6):669. doi: 10.3390/biom14060669. 

Neumann AM, Kebbach M, Bader R, Hildebrandt G, Wree A. Evaluation of 3D Footprint Morphology of Knee-Related Muscle Attachments Based on CT Data Reconstruction: A Feasibility Study. Life (Basel). 2024 Jun 19;14(6):778. doi: 10.3390/life14060778. 

Franziska Anna Seigfried and Stefan Britsch. The Role of Bcl11 Transcription Factors in Neurodevelopmental Disorders, Biology 2024, doi: 10.3390/biology13020126,  2024 Feb 17.

Artemis Koumoundourou, Märt Rannap, Elodie De Bruyckere, Sigrun Nestel, Carsten Reissner, Alexei V Egorov, Pengtao Liu, Markus Missler, Bernd Heimrich, Andreas Draguhn, Stefan Britsch. Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/ C1ql2/Nrxn3(25b+) pathway, Elife 2024, Feb 15. doi: 10.7554/elife.89854.

2023

Wiegreffe C, Ehricke S, Schmid L, Andraschke J, Britsch S. Using  i -GONAD for Cell-Type-Specific and Systematic Analysis of Developmental Transcription Factors In Vivo  Biology 2023, 12(9), 1236 doi:  10.3390/biology12091236 . Epub 2023 Sept 13.

2022

Wiegreffe C, Wahl T, Joos NS, Bonnefont J, Liu P, Britsch S. Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6-dependent pathway  EMBO Rep 2022 3;23(8):e54104 doi: 10.15252/embr.202154104. Epub 2022 Jun 29.

Seyfang M, Dreyhaupt J, Wiegreffe, C Rudolph H, Luthardt RG, Kuhn K. Quantification of MRP8 in immunohistologic sections of peri-implant soft tissue: Development of a novel automated computer analysis method and of its validation procedure. Comput Biol Med 2022; 148:105861. doi: 10.1016/j.compbiomed.2022.105861.Epub 2022 Jul 19. 

2021

Tolve M, Ulusoy A, Patikas N, Islam KUS, Bodea GO, Öztürk E, Broske B, Mentani A, Wagener A, van Loo KMJ, Britsch S, Liu P, Khaled WT, Metzakopian E, Baader SL, Di Monte DA, Blaess S. The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons. Cell Reports 2021; 36:109697. doi.10.1016/j.celrep.2021.109697

Bartelt-Kirbach B, Wiegreffe C, Birk S, Baur T, Moron M, Britsch S, Golenhofen N. HspB5/αB-crystalin phosphorylation at S45 and S59 is essential for protection of the dendritic tree of rat hippocampal neurons. J Neurochem 2020; (Nov 21). doi: 10.1111/jinc.15247 

2020

Baden T, Maina MB, Maia Chagas A, Mohammed YG, Auer TO, Silbering A, von Tobel L, Pertin M, Hartig R, Aleksic J, Akinrinade I, Awadelkareem MA, Koumoundourou A, Jones A, Arieti F, Beale A, Münch D, Salek SC, Yusuf S, Prieto-Godino LL. TRend in Africa: Toward a Truly Global (Neuro)science Community. Neuron 2020; 107(3): 412-416; doi: 10.1016/j.neuron.2020.06.026.

Simon R, Wiegreffe C, Britsch, S. Bcl11 transcription factors regulate cortical development and function. Front. Mol. Neurosci. 13:51. 2020 Apr 8; doi: 10.3389/fnmol.2020.00051.

2019

Panther P, Kuehne M, Voges J, Nullmeier S, Kaufmann J, Hausmann J, Bittner D, Galazky I, Heinze HJ, Kupsch A, Zaehle T. Electric stimulation of the medial forebrain bundle influences sensorimotor gaiting in humans. BMC Neurosci. 2019 Apr 29;20(1):20. doi: 10.1186/s12868-019-0503-y.

Prozorovski T, Giners J, Lukas D, Götze P, Koop B, Graf J, Schneider R, Franke K, Schumacher S, Britsch S, Hartung HP, Kürt P, Berndt C, Aktas O. Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells  Neuroscience Letters, jneulet.2019.04.007 .

2018

Lessel D, Gehbauer C, Bramswig NC, Schluth-Bolard C, Venkataramanappa S, van Gassen KLI, Hempel M, Haack TB, Baresic A, Genetti CA, Funari MFA, Lessel I, Kuhlmann L, Simon R, Liu P, Denecke J , Kuechler A, de Kruijff I, Shoukier M, Lek M, Mullen T, Lüdecke HJ, Lerario AM, Kobbe R, Krieger T, Demeer B, Lebrun M, Keren B, Nava C, Buratti J, Afenjar A, Shinawi M, Guillen Sacoto MJ, Gauthier J, Hamdan FF, Laberge AM, Campeau PM, Louie RJ, Cathey SS, Prinz I , Jorge AAL, Terhal PA, Lenhard B, Wieczorek D, Strohm TM, Agrawal PB, Britsch S, Tolosa E, Kubisch C. BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells.  Brain  2018, 141; 2299-2311.

De Bruyckere E, Simon R, Nestel S, Heimrich B, Kätzel D, Egorov AV, Liu P, Jenkins NA, Copeland NG, Schwegler H, Draguhn A, Britsch S. Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2. Front Mol Neurosc  2018, 11; 103.

Armacki M, Trugenberger AK, Ellwanger AK, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Groß R, Barth T, Lechel A, Walter BM, Kraus JM, Wiegreffe C, Grimm J, Scheffold A, Schneider MR, Peuker K, Zeißig S, Britsch S, Rose-John S, Vettorazzi S, Wolf E, Tannapfel A, Steinestel K, Reber SO, Walther P, Kestler HA, Radermacher P, Barth TF, Huber-Lang M, Kleger A, Seufferlein T. Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.  J Clin Invest  2018, Nov 1;128(11): 5065-5072. 

Rich CA, Perera SN, Andratschke J, Stolt CC, Buehler DP, Southard-Smith EM, Wegner M, Britsch S, Baker CVH.  Olfactory ensheathing cells abutting the embryonic olfactory bulb express Frzb, whose deletion disrupts olfactory axon targeting.  Glia  2018, 23515.

Wolf R, Dobrowolny H, Nullmeier S, Bogerts B, Schwegler H. Effects of neonatal excitotoxic lesions in ventral thalamus on social interaction in the rat. Eur Arch Psychiatry Clin Neurosci  2018, Aug; 268(5):461-470.

2016

Simon R, Baumann L, Fischer J, Seigfried FA, De Bruyckere E, Liu P, Jenkins NA, Copeland NG, Schwegler H, Britsch S. Structure-function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2.  Genes Brain Behavior  2016, 15; p 405-419 .

2015

Wiegreffe C, Simon R, Peschkes K, Kling C, Strehle M, Cheng J, Srivatsa L, Liu P, Jenkins NA, Copeland NG, Tarabykin V, Britsch S. Bcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c .  Neuron  87:311–325

Venkataramanappa S, Simon R, Britsch S. Ex utero electroporation and oganotypic slice culture of mouse hippocampal tissue. J Vis Exp : e52550 

Sagar, Pröls F, Wiegreffe C, Scaal M. Communication between distant epithelial cells by filopodia-like protrusions during embryonic development.  Development  142: 665-671

2014

Imhof J, Huber F, Reichelt M, Gershenzon J, Wiegreffe C, Lächler K, Binder S. The small subunit 1 of the Arabidopsis isopropylmalate isomerase is required for development and the early stages of glucosinolate formation.  PloS ONE  9: e91071 

2013

Del Barrio MG, Bourane S, Grossmann K, Schüle R, Britsch S, O’Leary DD, Goulding M. A transcription factor code defines nine sensory interneuron subtypes in the mechanosensory area of ​​the spinal cord.  PLoS ONE  8: e77928

2012

Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A.  The ERK3 (MAPK6) – MAPKAP kinase 5 signaling complex regulates septin function and dendrite morphology.  Mol Cell Biol  32:2467–2478

Simon R, Brylka H, ​​Schwegler H, Venkataramanappa S, Andratschke J, Wiegreffe C, Liu P, Fuchs E, Jenkins NA, Copeland NG, Birchmeier C, Britsch S. A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis.  EMBO J  31:2922-2936

John A, Brylka H, ​​Wiegreffe C, Simon R, Liu P, Jüttner R, Crenshaw III, EB, Luyten FP, Jenkins NA, Copeland NG, Birchmeier C, Britsch S. Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development.  Development 139: 1801-1811

2011

Schmidt C, Reinehr M, Leucht O, Behrendt N, Geiler S, Britsch S. MyMiCROscope-intelligent virtual microscopy in a blended learning model at Ulm University.  Ann Anat  193: 395-402

Simon R, Britsch S, Bergemann A. Ablation of  Sax2  gene expression prevents diet-induced obesity.  FEBS Journal 278: 371-382

2010

Podrygajlo G, Wiegreffe C, Scaal M, Bicker G. Integration of human model neurons (NT2) into embryonic chick nervous system.  Dev Dyn  239: 496-504 

2009

Wolfram U, Schmitz B, Heuer F, Reinehr M, Wilke HJ.  Vertebral trabecular main orientation can be determined from clinical CT datasets using the gradient structure tensor and not the inertia tensor-A case study.  J  Biomech 42:1390-1396

2008

Schweickert A, Deißler K, Britsch S, Albrecht M, Ehmann H, Mauch V, Gaio U, Blum M. Left-asymmetric expression of  Galanin  in the linear heart tube of the mouse embryo is independent of the Nodal coreceptor gene cryptic.  Dev Dyn  237:3557–3564

Strehle M, Britsch S. Animal models in biomedical research. In: Ganten D, Ruckpaul K (eds.)  Handbook of Molecular Medicine, Vol. 1, Fundamentals of Molecular Medicine . 3rd edition. Springer-Verlag, Heidelberg, New York

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