Modeling human neurodevelopmental
disorders in the mouse brain

n this research project we are investigating Bcl11a and associated gene regulatory networks in cerebellar development. In addition to its established function in motor learning and coordination, the cerebellum has recently been implicated to play a role in cognitive and affective processes. BCL11A mutations lead to Dias Logan-Syndrome characterized by intellectual disability and structural defects within the cerebellum. As cerebellar development continues over a comparatively long developmental period at postnatal stages, it is also particularly vulnerable to environmental stress, that can result in cerebellar dysfunction. We are applying genetic models, molecular biology, histology, microscopy, and behavioral experiments to study genetic pathways and their function at different stages of cerebellar development. We expect this project to uncover key molecular controls of cerebellar development and lead to a better understanding of cerebellar dysfunction in the context of genetic but also environmentally related disorders.

Project Team
Dr. Franziska Seigfried (Project Lead)
Anna Dieterich
Tabea Hohmann
Anna Kammerer
Diana Krattenmacher
Sophia Lisovaya

Related Publications
Lessel et al., 2018 Brain
Simon et al., 2020 Frontiers in Mol. Neuroscience
Seigfried et. al., 2024 Biology



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